Acute Respiratory Distress Syndrome (ARDS)

December 30, 2020

This is a The Brighton Collaboration Case Definition of the term “Acute Respiratory Distress Syndrome (ARDS)” to be utilized in the evaluation of adverse events following immunization. The case definition was developed by a group of experts convened by the Coalition for Epidemic Preparedness Innovations (CEPI) as part of the Safety Platform for Emergency vACcines (SPEAC) project, in the context of active development of vaccines for COVID-19 and other emerging pathogens. The case definition format of the Brighton Collaboration was followed to develop a consensus case definition and defined levels of diagnostic certainty, after an exhaustive review of the literature and expert consultation.

Publication

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Companion Guide

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The case definition companion guide collates into a single document the SPEAC ARDS resources (ICD9/10 CM, MedDRA and SNOMEDCT-US codes, background incidence, risk factors), tools (Case Report & interpretation form, tabular summary of key case definition criteria and algorithm for level of certainty determination, pictorial level of certainty algorithm) and guidance (real-time investigation, data collection, analysis and presentation).